Metabolism: Oxycodone hydrochloride is extensively metabolized to noroxycodone, oxymorphone, and their glucuronides. The key circulating metabolite is noroxycodone with an AUC ratio of 0.

Actual physical dependence is manifested by withdrawal signs following abrupt discontinuation of a drug or on administration of an antagonist. Actual physical dependence and tolerance are common during Persistent opioid therapy.

Oxycodone is existing in breast milk. Printed lactation studies report variable concentrations of oxycodone in breast milk with administration of rapid-launch oxycodone to nursing moms while in the early postpartum period. The lactation scientific tests didn't evaluate breastfed infants for possible adverse reactions. Lactation scientific tests haven't been conducted with prolonged–launch oxycodone, including OXYCONTIN, and no info is offered on the results of your drug on the breastfed toddler or the results on the drug on milk generation.

The concomitant use of anticholinergic drugs may perhaps maximize threat of urinary retention and/or serious constipation, which may bring on paralytic ileus.

Before you start getting this medication, talk to your medical doctor or pharmacist if you should quit or improve the way you make use of your other opioid medication(s).

This information is not personal clinical advice and does not substitute for the recommendation of your respective wellbeing care Expert. Often request your health treatment Skilled for full information about this products and also your particular overall health demands.

This document does not incorporate all get more info feasible Negative effects and Other people may possibly manifest. Look at with your medical doctor For added details about Unwanted side effects.

Advise patients and caregivers not to improve opioid dosage without 1st consulting a clinician. Suggest people to hunt clinical attention whenever they working experience signs and symptoms of hyperalgesia, which includes worsening discomfort, enhanced sensitivity to discomfort, or new suffering [see WARNINGS AND PRECAUTIONS and more info ADVERSE REACTIONS].

Using OXYCONTIN isn't advisable for sufferers read more using MAOIs or within 14 times of stopping such remedy.

If a CYP3A4 inhibitor is discontinued, consider escalating the OXYCONTIN dosage here until eventually stable drug effects are accomplished. Assess for signs of opioid withdrawal.

Talk about The supply of naloxone for your emergency remedy of opioid overdose with the client and caregiver and assess the prospective will need for entry to naloxone, equally when initiating and renewing cure with OXYCONTIN. Notify individuals and caregivers about the various methods to acquire naloxone as permitted by individual state naloxone dispensing and prescribing specifications or suggestions (e.

You can find considerable inter-affected person variability within the relative potency of various opioid drugs and formulations. For that reason, a conservative strategy is encouraged when analyzing the entire daily dosage of OXYCONTIN.

Tell people and caregivers that most likely lethal additive outcomes may read more well manifest if OXYCONTIN is utilised with benzodiazepines or other CNS depressants, together with Liquor, and never to utilize these concomitantly Until supervised by a healthcare service provider [see WARNINGS AND Safeguards and DRUG INTERACTIONS].

Chosen from data bundled with authorization and copyrighted by Initially Databank, Inc. This copyrighted materials continues to be downloaded from a licensed details supplier and isn't for distribution, apart from as may be approved by the applicable terms of use.